ABX-1431
| CAS No. | 1446817-84-0 | Cat. No. | BCP29967 |
| Name | ABX-1431 | ||
| Synonyms | ABX1431;ABX 1431; | ||
| Formula | C20H22F9N3O2 | M. Wt | 507.40 |
| Description | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | MAGL | ||
Structure
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