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CAS No. | 1446817-84-0 | Cat. No. | BCP29967 |
Name | ABX-1431 | ||
Synonyms | ABX1431;ABX 1431; | ||
SMILES | C1CCN(C1)C2=C(C=CC(=C2)C(F)(F)F)CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F | ||
Chemical Name | |||
Formula | C20H22F9N3O2 | M. Wt | 507.40 |
Purity | 98% | Storage | Store at 4-8°C |
Description | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. |
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