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ABX-1431 Chemical Structure

ABX-1431

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29967CAS No. :1446817-84-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1446817-84-0 Cat. No. BCP29967
Name ABX-1431
Synonyms ABX1431;ABX 1431;
SMILES C1CCN(C1)C2=C(C=CC(=C2)C(F)(F)F)CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F
Chemical Name
Formula C20H22F9N3O2 M. Wt 507.40
Purity 98% Storage Store at 4-8°C
Description ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.
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