L-660711
| CAS No. | 135028-15-8 | Cat. No. | BCP30001 |
| Name | L-660711 | ||
| Synonyms | L660711;L 660711;MK-571;MK571;MK 571; (E)-5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid; | ||
| Formula | C26H27ClN2O3S2 | M. Wt | 515.09 |
| Description | MK-571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Leukotriene Receptor | ||
Structure
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