Nedisertib
| CAS号 | 1637542-33-6 | 货号 | BCP30542 |
| 中文名 | Nedisertib | ||
| 英文名 | Nedisertib | ||
| 中文别名 | |||
| 英文别名 | MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; | ||
| 分子式 | C24H21ClFN5O3 | 分子量 | 481.91 |
| 生物活性 | Nedisertib, also known as M-3814, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA PK | ||
结构式
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