卡利奇霉素
| CAS号 | 108212-75-5 | 货号 | BCP30641 |
| 中文名 | 卡利奇霉素 | ||
| 英文名 | Calicheamicin | ||
| 中文别名 | 卡奇霉素; | ||
| 英文别名 | Calicheamicin γ1;Calicheamicin gamma(1,I); Calichemicin gamma1; Calicheamicin gamma(1)I;Calicheamicin γ1I; | ||
| 分子式 | C55H74IN3O21S4 | 分子量 | 1368.35 |
| 生物活性 | Calicheamicin is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule. | ||
| 信号通路 | Cell Cycle/DNA Damage Apoptosis Pathway Others Pathway | ||
| 靶 点 | DNA Alkylator/Crosslinker Apoptosis Inducer ADC Related | ||
结构式
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