卡利奇霉素新

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货号：BCP30641CAS号：108212-75-5纯度：98%

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CAS号	108212-75-5	货号	BCP30641
中文名	卡利奇霉素
英文名	Calicheamicin
中文别名	卡奇霉素;
英文别名	Calicheamicin γ1;Calicheamicin gamma(1,I); Calichemicin gamma1; Calicheamicin gamma(1)I;Calicheamicin γ1I;
SMILES	CCNC1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NOC5CC(C(C(O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)OC7C(C(C(C(O7)C)O)OC)O)I)C)O)O
化学名称
分子式	C55H74IN3O21S4	分子量	1368.35
纯度	98%	配送	惯例下常温包邮
产品描述	Calicheamicin is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule.

卡利奇霉素 新