Theophylline

CAS No.	58-55-9	Cat. No.	BCP30664
Name	Theophylline
Synonyms	Theo-24;1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione ;1,3-Dimethylxanthine;1,3-dimethyl-xanthin;
Formula	C7H8N4O2	M. Wt	180.16

Description	Theophylline is a drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine. Like other methylated xanthine derivatives, theophylline is both a competitive nonselective phosphodiesterase inhibitor, which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and inhibits leukotriene synthesis, and reduces inflammation and innate immunity nonselective adenosine receptor antagonist, antagonizing A1, A2, and A3 receptors almost equally, which explains many of its cardiac effects.
Pathways	Protease/Metabolic Enzyme GPCR/G Protein Others Pathway
Targets	Phosphodiesterase/PDE Adenosine Receptor Autophagy

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