DMX-5084
| CAS No. | 2306178-56-1 | Cat. No. | BCP30841 |
| Name | DMX-5084 | ||
| Synonyms | DMX 5084；DMX5084; | ||
| Formula | C21H19N3O3 | M. Wt | 361.39 |
| Description | DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice. | ||
| Pathways | MAPK Pathway | ||
| Targets | MAP4K | ||
Structure
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