JNJ-10229570

  • Chemical Properties
CAS No. 524923-88-4 Cat. No. BCP30848
Name JNJ-10229570
Synonyms JNJ10229570; JNJ 10229570;
Formula C22H19N3O2S M. Wt 389.47
  • Biological Activity
Description JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
Pathways GPCR/G Protein 
Targets Melanocortin Receptor 

Structure

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