UAMC-3203 hydrochloride

CAS No.	2271358-65-5	Cat. No.	BCP30942
Name	UAMC-3203 hydrochloride
Synonyms	UAMC-3203 HCl ;UAMC3203 HCl ;UAMC 3203 HCl ;UAMC 3203 hydrochloride ;UAMC3203 hydrochloride;
Formula	C25H38ClN5O2S	M. Wt	508.12

Description	UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.UAMC-3203 is a Ferroptosis Inhibitor wtih IC50 = 12 nM. UAMC-3203 showed an improved protection compared to Fer-1 against multiorgan injury in mice. No toxicity was observed in mice after daily injection of 39 (UAMC-3203) for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models.
Pathways	Apoptosis Pathway
Targets	Ferroptosis

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