UAMC-3203 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2271358-65-5 | Cat. No. | BCP30942 |
| Name | UAMC-3203 hydrochloride | ||
| Synonyms | UAMC-3203 HCl ;UAMC3203 HCl ;UAMC 3203 HCl ;UAMC 3203 hydrochloride ;UAMC3203 hydrochloride; | ||
| SMILES | O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O.Cl | ||
| Chemical Name | |||
| Formula | C25H38ClN5O2S | M. Wt | 508.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.UAMC-3203 is a Ferroptosis Inhibitor wtih IC50 = 12 nM. UAMC-3203 showed an improved protection compared to Fer-1 against multiorgan injury in mice. No toxicity was observed in mice after daily injection of 39 (UAMC-3203) for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models. | ||
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