PF-06869206
| CAS No. | 2227425-05-8 | Cat. No. | BCP31135 |
| Name | PF-06869206 | ||
| Synonyms | PF 06869206; PF06869206; | ||
| Formula | C15H14ClF3N4O2 | M. Wt | 374.74 |
| Description | PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). PF-06869206 is the first orally bioavailable selective NaPi2a inhibitor and, as such, represents a pharmacological tool to probe the functional effects of selective NaPi2a inhibition in vivo. PF-06869206 showed a balance of attributes with 380 nM NaPi2a inhibition potency, excellent subtype selectivity, and acceptable aqueous solubility (46 μM). Furthermore, permeability is good (14 × 10−6 cm/s), and RLM clearance is low (<14 μL/min/mg; HLM = 39 μL/min/mg). | ||
| Pathways | Ion Channel/Membrane Transporter Others Pathway | ||
| Targets | Sodium Channel Others | ||
Structure
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