PF-06869206 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2227425-05-8 | Cat. No. | BCP31135 |
| Name | PF-06869206 | ||
| Synonyms | PF 06869206; PF06869206; | ||
| SMILES | CC1=C(C2=C(N1)C(=C(C(=N2)C(F)(F)F)C#N)N3CCOC(C3)CO)Cl | ||
| Chemical Name | |||
| Formula | C15H14ClF3N4O2 | M. Wt | 374.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). PF-06869206 is the first orally bioavailable selective NaPi2a inhibitor and, as such, represents a pharmacological tool to probe the functional effects of selective NaPi2a inhibition in vivo. PF-06869206 showed a balance of attributes with 380 nM NaPi2a inhibition potency, excellent subtype selectivity, and acceptable aqueous solubility (46 μM). Furthermore, permeability is good (14 × 10−6 cm/s), and RLM clearance is low (<14 μL/min/mg; HLM = 39 μL/min/mg). | ||
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