USP25 and 28 inhibitor AZ-2
| CAS No. | 2165322-95-0 | Cat. No. | BCP31313 |
| Name | USP25 and 28 inhibitor AZ-2 | ||
| Synonyms | USP25/28 inhibitor AZ2；AZ2；AZ-2；AZ 2; | ||
| Formula | C17H17BrF3NO3 | M. Wt | 420.23 |
| Description | USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DUB | ||
Structure
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