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USP25 and 28 inhibitor AZ-2 Chemical Structure

USP25 and 28 inhibitor AZ-2

Data Sheet For research use only. Not for human use.
Cat. No. :BCP31313CAS No. :2165322-95-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2165322-95-0 Cat. No. BCP31313
Name USP25 and 28 inhibitor AZ-2
Synonyms USP25/28 inhibitor AZ2;AZ2;AZ-2;AZ 2;
SMILES C1=CC(=CC(=C1)OC(F)(F)F)COC2=C(C=C(C=C2)Br)CNCCO
Chemical Name
Formula C17H17BrF3NO3 M. Wt 420.23
Purity 98% Storage Store at 4-8°C
Description USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
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