PLX5622
| CAS No. | 1303420-67-8 | Cat. No. | BCP31350 |
| Name | PLX5622 | ||
| Synonyms | PLX-5622; PLX 5622; | ||
| Formula | C21H19F2N5O | M. Wt | 395.41 |
| Description | PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. PLX5622 has been shown to eliminate microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | cFMS | ||
Structure
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