RGX-104
| CAS号 | 610318-54-2 | 货号 | BCP31854 |
| 中文名 | RGX-104 | ||
| 英文名 | RGX-104 | ||
| 中文别名 | |||
| 英文别名 | RGX104; RGX 104; SB742881; SB-742881; SB 742881; | ||
| 分子式 | C34H33ClF3NO3 | 分子量 | 596.09 |
| 生物活性 | RGX-104 is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | LXR | ||
结构式
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