RGX-104 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP31854CAS号：610318-54-2纯度：98%

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CAS号	610318-54-2	货号	BCP31854
中文名	RGX-104
英文名	RGX-104
中文别名
英文别名	RGX104; RGX 104; SB742881; SB-742881; SB 742881;
SMILES	CC(CCOC1=CC=CC(=C1)CC(=O)O)N(CC2=C(C(=CC=C2)C(F)(F)F)Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4
化学名称
分子式	C34H33ClF3NO3	分子量	596.09
纯度	98%	配送	惯例下常温包邮
产品描述	RGX-104 is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.