ERK5-IN-2
| CAS No. | 1888305-96-1 | Cat. No. | BCP32587 |
| Name | ERK5-IN-2 | ||
| Synonyms | ERK5-IN 2; ERK5 IN-2; | ||
| Formula | C17H11BrFN3O2 | M. Wt | 388.19 |
| Description | ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis. | ||
| Pathways | MAPK Pathway | ||
| Targets | MEK/ERK | ||
Structure
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