GIBH-130
| CAS No. | 1252608-59-5 | Cat. No. | BCP32635 |
| Name | GIBH-130 | ||
| Synonyms | GIBH 130; GIBH130; | ||
| Formula | C20H20N6O | M. Wt | 360.41 |
| Description | GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents. | ||
| Pathways | Others Pathway | ||
| Targets | Interleukin Related | ||
Structure
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