GIBH-130 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1252608-59-5 | Cat. No. | BCP32635 |
| Name | GIBH-130 | ||
| Synonyms | GIBH 130; GIBH130; | ||
| SMILES | CC1=CC(=NN=C1C(=O)N2CCN(CC2)C3=NC=CC=N3)C4=CC=CC=C4 | ||
| Chemical Name | |||
| Formula | C20H20N6O | M. Wt | 360.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents. | ||
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