TH263
  • 化学数据
CAS号 313520-94-4 货号 BCP32731
中文名 TH263
英文名 TH263
中文别名
英文别名 TH-263;TH 263;
分子式 C21H20N2O3S 分子量 380.46
  • 用途
生物活性 TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. LIM kinases belong to the family of cytoplasmic tyrosine-like kinases with dual specificity (serine/threonine and tyrosine). However, known LIMK substrate are usually phosphorylated at serine and threonine residues LIM kinases comprises LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) which show 50% sequence identity in human. Both LIMK1 and LIMK2 present with a unique domain organization containing two N-terminal LIM domains, a PDZ domain, a proline/serine-rich domain and a C-terminal kinase domain.
信号通路 Cell Cycle/DNA Damage 
靶 点 LIMK 

结构式

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