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| CAS号 | 313520-94-4 | 货号 | BCP32731 |
| 中文名 | TH263 | ||
| 英文名 | TH263 | ||
| 中文别名 | |||
| 英文别名 | TH-263;TH 263; | ||
| SMILES | C1=CC=C(C=C1)CNC(=O)C2=CC=C(C=C2)S(=O)(=O)NCC3=CC=CC=C3 | ||
| 化学名称 | |||
| 分子式 | C21H20N2O3S | 分子量 | 380.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. LIM kinases belong to the family of cytoplasmic tyrosine-like kinases with dual specificity (serine/threonine and tyrosine). However, known LIMK substrate are usually phosphorylated at serine and threonine residues LIM kinases comprises LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) which show 50% sequence identity in human. Both LIMK1 and LIMK2 present with a unique domain organization containing two N-terminal LIM domains, a PDZ domain, a proline/serine-rich domain and a C-terminal kinase domain. | ||
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