SBI-115
| CAS No. | 882366-16-7 | Cat. No. | BCP32736 |
| Name | SBI-115 | ||
| Synonyms | SBI 115; SBI115; | ||
| Formula | C14H13ClN2O4S | M. Wt | 340.78 |
| Description | SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation; our data suggest that a TGR5 antagonist alone or concurrently with somatostatin receptor agonists represents a potential therapeutic approach in polycystic liver disease. | ||
| Pathways | GPCR/G Protein | ||
| Targets | TGR5 | ||
Structure
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