PTC596
| CAS No. | 1610964-64-1 | Cat. No. | BCP33231 |
| Name | PTC596 | ||
| Synonyms | PTC-596; PTC 596;Unesbulin; | ||
| Formula | C19H13F5N6 | M. Wt | 420.34 |
| Description | PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. | ||
| Pathways | Apoptosis Pathway | ||
Structure
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