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CAS No. | 1610964-64-1 | Cat. No. | BCP33231 |
Name | PTC596 | ||
Synonyms | PTC-596; PTC 596;Unesbulin; | ||
SMILES | CC1=NC2=C(N1C3=NC(=C(C(=N3)NC4=CC=C(C=C4)C(F)(F)F)F)N)C=C(C=C2)F | ||
Chemical Name | |||
Formula | C19H13F5N6 | M. Wt | 420.34 |
Purity | 98% | Storage | Store at 4-8°C |
Description | PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. |
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