琥珀酸莫博替尼
| CAS号 | 2389149-74-8 | 货号 | BCP33315 |
| 中文名 | 琥珀酸莫博替尼 | ||
| 英文名 | Mobocertinib succinate | ||
| 中文别名 | 莫博替尼琥珀酸; | ||
| 英文别名 | TAK-788 succinate; AP32788 succinate;TAK 788 succinate; AP 32788 succinate;TAK788 succinate; AP-32788 succinate; | ||
| 分子式 | C36H45N7O8 | 分子量 | 703.78 |
| 生物活性 | Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.Mobocertinib, also known as TAK-788 and AP32788, is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. TAK-788 exhibits antitumor activity in pts with EGFR exon 20 insertions with an AE profile consistent with other EGFR TKIs. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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