nAChR agonist 1
| CAS No. | 1394371-75-5 | Cat. No. | BCP33344 |
| Name | nAChR agonist 1 | ||
| Synonyms | DUN71755; DUN 71755; DUN-71755; | ||
| Formula | C20H18ClNO3S2 | M. Wt | 419.94 |
| Description | nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease. | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | nAChR | ||
Structure
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