nAChR agonist 1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1394371-75-5 | Cat. No. | BCP33344 |
| Name | nAChR agonist 1 | ||
| Synonyms | DUN71755; DUN 71755; DUN-71755; | ||
| SMILES | NS(C1=CC=C(C2=C(C(CC)=O)SC(C3=CC=C(Cl)C=C3)=C2C)C=C1)(=O)=O | ||
| Chemical Name | |||
| Formula | C20H18ClNO3S2 | M. Wt | 419.94 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease. | ||
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