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nAChR agonist 1 Chemical Structure

nAChR agonist 1

Data Sheet For research use only. Not for human use.
Cat. No. :BCP33344CAS No. :1394371-75-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1394371-75-5 Cat. No. BCP33344
Name nAChR agonist 1
Synonyms DUN71755; DUN 71755; DUN-71755;
SMILES NS(C1=CC=C(C2=C(C(CC)=O)SC(C3=CC=C(Cl)C=C3)=C2C)C=C1)(=O)=O
Chemical Name
Formula C20H18ClNO3S2 M. Wt 419.94
Purity 98% Storage Store at 4-8°C
Description nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease.
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