AUY954
| CAS号 | 820240-77-5 | 货号 | BCP33492 |
| 中文名 | AUY954 | ||
| 英文名 | AUY954 | ||
| 中文别名 | |||
| 英文别名 | NVP-AUY954;AUY-954;AUY 954; | ||
| 分子式 | C25H20F3NO2S | 分子量 | 455.49 |
| 生物活性 | AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | S1P Receptor | ||
结构式
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