Encequidar mesylate
| CAS No. | 849675-87-2 | Cat. No. | BCP33772 |
| Name | Encequidar mesylate | ||
| Synonyms | HM-30181 mesylate;HM30181 mesylate;HM 30181 mesylate; HM30181A mesylate; | ||
| Formula | C39H40N6O10S | M. Wt | 784.83 |
| Description | Encequidar is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under clinical trials. | ||
| Related Products | 2097125-58-9（Encequidar mesylate monohydrate） 849675-66-7（Encequidar） | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | P glycoprotein | ||
Structure
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