UNC2541

  • Chemical Properties
CAS No. 1612782-86-1 Cat. No. BCP33929
Name UNC2541
Synonyms UNC-2541; UNC 2541;
Formula C24H34FN7O2 M. Wt 471.58
  • Biological Activity
Description UNC2541 is a potent and MerTK-specific inhibitor that exhibits sub-micromolar inhibitory activity in the cell-based ELISA. In addition, an X-ray structure of MerTK protein in complex with 11 was resolved to show that these macrocycles bind in the MerTK ATP pocket. UNC2541 showed IC50 MerTH=4.4 nM; IC50 AXL = 120 nM; IC50 TYRO3 = 220 nM; IC50 FLT3 = 320 nM.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets TAM Receptor 

Structure

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