UNC2541 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1612782-86-1 | Cat. No. | BCP33929 |
| Name | UNC2541 | ||
| Synonyms | UNC-2541; UNC 2541; | ||
| SMILES | C1CCCNC2=NC=C(C(=N2)NCCCCC(C(=O)NCC1)N)C(=O)NCC3=CC=C(C=C3)F | ||
| Chemical Name | |||
| Formula | C24H34FN7O2 | M. Wt | 471.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | UNC2541 is a potent and MerTK-specific inhibitor that exhibits sub-micromolar inhibitory activity in the cell-based ELISA. In addition, an X-ray structure of MerTK protein in complex with 11 was resolved to show that these macrocycles bind in the MerTK ATP pocket. UNC2541 showed IC50 MerTH=4.4 nM; IC50 AXL = 120 nM; IC50 TYRO3 = 220 nM; IC50 FLT3 = 320 nM. | ||
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