EIDD-1931
| CAS号 | 3258-02-4 | 货号 | BCP33953 |
| 中文名 | EIDD-1931 | ||
| 英文名 | EIDD-1931 | ||
| 中文别名 | N4-羟基胞苷; | ||
| 英文别名 | N4-Hydroxycytidine;NHC;Beta-d-N4-hydroxycytidine; EIDD 1931; EIDD1931; N4-Hydroxycytidine; β-D-N4-hydroxycytidine; Uridine, 4-oxime; NHC; EIDD-2801-metabolite; EIDD2801-metabolite; EIDD 2801-metabolit; | ||
| 分子式 | C9H13N3O6 | 分子量 | 259.22 |
| 生物活性 | Beta-d-N4-hydroxycytidine is a promising COVID-19 inhibitor. EIDD-1931 has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir. In mice infected with SARS-CoV or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), improved pulmonary function, and reduced virus titer and body weight loss. Decreased MERS-CoV yields in vitro and in vivo were associated with increased transition mutation frequency in viral but not host cell RNA, supporting a mechanism of lethal mutagenesis in CoV. The potency of NHC/EIDD-2801 against multiple coronaviruses and oral bioavailability highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Influenza Virus | ||
结构式
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