EIDD-1931 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP33953CAS号：3258-02-4纯度：98%

规格	价格(CNY)	是否现货	购买咨询
100.00 mg	￥1200.00	In-stock	购买咨询
500.00 mg	￥2000.00	In-stock	购买咨询
1.00 g	￥3000.00	In-stock	购买咨询

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CAS号	3258-02-4	货号	BCP33953
中文名	EIDD-1931
英文名	EIDD-1931
中文别名	N4-羟基胞苷;
英文别名	N4-Hydroxycytidine;NHC;Beta-d-N4-hydroxycytidine; EIDD 1931; EIDD1931; N4-Hydroxycytidine; β-D-N4-hydroxycytidine; Uridine, 4-oxime; NHC; EIDD-2801-metabolite; EIDD2801-metabolite; EIDD 2801-metabolit;
SMILES	C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
化学名称
分子式	C9H13N3O6	分子量	259.22
纯度	98%	配送	惯例下常温包邮
产品描述	Beta-d-N4-hydroxycytidine is a promising COVID-19 inhibitor. EIDD-1931 has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir. In mice infected with SARS-CoV or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), improved pulmonary function, and reduced virus titer and body weight loss. Decreased MERS-CoV yields in vitro and in vivo were associated with increased transition mutation frequency in viral but not host cell RNA, supporting a mechanism of lethal mutagenesis in CoV. The potency of NHC/EIDD-2801 against multiple coronaviruses and oral bioavailability highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses.