TAS-115 mesylate
| CAS No. | 1688673-09-7 | Cat. No. | BCP34015 |
| Name | TAS-115 mesylate | ||
| Synonyms | TAS 115 methanesulfonate;TAS-115 methanesulfonate;TAS115 mesylate; | ||
| Formula | C28H27FN4O7S2 | M. Wt | 614.66 |
| Description | TAS-115 is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | c Met VEGFR | ||
Structure
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