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TAS-115 mesylate Chemical Structure

TAS-115 mesylate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP34015CAS No. :1688673-09-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1688673-09-7 Cat. No. BCP34015
Name TAS-115 mesylate
Synonyms TAS 115 methanesulfonate;TAS-115 methanesulfonate;TAS115 mesylate;
SMILES CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F.CS(=O)(=O)O
Chemical Name
Formula C28H27FN4O7S2 M. Wt 614.66
Purity 98% Storage Store at 4-8°C
Description TAS-115 is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented.
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