LMP744 hydrochloride
| CAS号 | 308246-57-3 | 货号 | BCP34016 |
| 中文名 | LMP744 hydrochloride | ||
| 英文名 | LMP744 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | LMP-744 hydrochloride; LMP-744 HCl; LMP744 HCl; LMP 744 HCl;MJ-III65 hydrochloride; NSC706744 hydrochloride; | ||
| 分子式 | C24H25ClN2O7 | 分子量 | 488.92 |
| 生物活性 | LMP-744 hydrochloride is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP-744 HCl produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP-744 HCl at nanomolar concentrations. Studies in human cells in culture found LMP-744 HCl to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP-744 HCl also exhibits antitumor activity in mouse tumor xenografts. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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