A 438079 Hydrochloride
| CAS No. | 899507-36-9 | Cat. No. | BCP34027 |
| Name | A 438079 Hydrochloride | ||
| Synonyms | A-438079 HCl;A438079 hydrochloride; | ||
| Formula | C13H10Cl3N5 | M. Wt | 342.61 |
| Description | A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease. | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | P2 Receptor | ||
Structure
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