A 438079 Hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 899507-36-9 | Cat. No. | BCP34027 |
| Name | A 438079 Hydrochloride | ||
| Synonyms | A-438079 HCl;A438079 hydrochloride; | ||
| SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl | ||
| Chemical Name | |||
| Formula | C13H10Cl3N5 | M. Wt | 342.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease. | ||
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