阿兹夫定
| CAS号 | 1011529-10-4 | 货号 | BCP34041 |
| 中文名 | 阿兹夫定 | ||
| 英文名 | Azvudine | ||
| 中文别名 | |||
| 英文别名 | RO-0622;RO 0622;RO0622; | ||
| 分子式 | C9H11FN6O4 | 分子量 | 286.22 |
| 生物活性 | Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1]. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Reverse Transcriptase | ||
结构式
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