HPK1-IN-22
| CAS号 | 2380300-79-6 | 货号 | BCP35846 |
| 中文名 | HPK1-IN-22 | ||
| 英文名 | HPK1-IN-22 | ||
| 中文别名 | |||
| 英文别名 | ZYF0033; | ||
| 分子式 | C26H30N4O2S | 分子量 | 462.61 |
| 生物活性 | HPK1-IN-22 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses. HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MAP4K | ||
结构式
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