HPK1-IN-22 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP35846CAS号：2380300-79-6纯度：98%

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CAS号	2380300-79-6	货号	BCP35846
中文名	HPK1-IN-22
英文名	HPK1-IN-22
中文别名
英文别名	ZYF0033;
SMILES	CC(O)(C)C#CC1=CC=CC(COC2=CC(C3=CN=C(C4CCN(C)CC4)S3)=CN=C2N)=C1
化学名称
分子式	C26H30N4O2S	分子量	462.61
纯度	98%	配送	惯例下常温包邮
产品描述	HPK1-IN-22 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses. HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model.