Leptomycin B

  • Chemical Properties
CAS No. 87081-35-4 Cat. No. BCP35974
Name Leptomycin B
Synonyms CI 940; LMB;Elactocin;Mantuamycin;
Formula C33H48O6 M. Wt 540.74
  • Biological Activity
Description Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells.
Pathways Ion Channel/Membrane Transporter Microbiology/Virology 
Targets Antifungal Antibiotic CRM1 

Structure

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