Leptomycin B
| CAS No. | 87081-35-4 | Cat. No. | BCP35974 |
| Name | Leptomycin B | ||
| Synonyms | CI 940; LMB;Elactocin;Mantuamycin; | ||
| Formula | C33H48O6 | M. Wt | 540.74 |
| Description | Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. | ||
| Pathways | Ion Channel/Membrane Transporter Microbiology/Virology | ||
| Targets | Antifungal Antibiotic CRM1 | ||
Structure
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