Leptomycin B New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 87081-35-4 | Cat. No. | BCP35974 |
| Name | Leptomycin B | ||
| Synonyms | CI 940; LMB;Elactocin;Mantuamycin; | ||
| SMILES | O=C(O)/C=C(C)/C[C@H](C)C(O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(CC)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O | ||
| Chemical Name | |||
| Formula | C33H48O6 | M. Wt | 540.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. | ||
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