GNE-495
  • 化学数据
CAS号 1449277-10-4 货号 BCP36075
中文名 GNE-495
英文名 GNE-495
中文别名
英文别名 GNE 495; GNE495;
分子式 C22H20FN5O2 分子量 405.42
  • 用途
生物活性 GNE-495 is a potent and selective MAP4K4 Inhibitor with efficacy in retinal angiogenesis. GNE-495 showed excellent potency and good PK and was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that were observed in the inducible Map4k4 knockout mice. Mitogen-activated protein kinase kinase kinase kinase (MAP4K4, or HGK), and its homologues Misshapen and MIG-15 have been shown to regulate a multitude of biological processes, including embryonic development,metabolism, inflammation, neural regeneration, angiogenesis, and cancer.
信号通路 MAPK Pathway 
靶 点 MAP4K 

结构式

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