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| CAS号 | 1449277-10-4 | 货号 | BCP36075 |
| 中文名 | GNE-495 | ||
| 英文名 | GNE-495 | ||
| 中文别名 | |||
| 英文别名 | GNE 495; GNE495; | ||
| SMILES | C1CC1C(=O)N2CC(C2)NC(=O)C3=CN=C(C4=C3C=CC(=N4)C5=CC(=CC=C5)F)N | ||
| 化学名称 | |||
| 分子式 | C22H20FN5O2 | 分子量 | 405.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | GNE-495 is a potent and selective MAP4K4 Inhibitor with efficacy in retinal angiogenesis. GNE-495 showed excellent potency and good PK and was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that were observed in the inducible Map4k4 knockout mice. Mitogen-activated protein kinase kinase kinase kinase (MAP4K4, or HGK), and its homologues Misshapen and MIG-15 have been shown to regulate a multitude of biological processes, including embryonic development,metabolism, inflammation, neural regeneration, angiogenesis, and cancer. | ||
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