BCL2 Degrader C5

  • Chemical Properties
CAS No. 2378801-85-3 Cat. No. BCP36383
Name BCL2 Degrader C5
Synonyms PROTAC Bcl2 degrader-1;
Formula C45H45BrN6O10S M. Wt 941.85
  • Biological Activity
Description BCL2 Degrader C5 is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Pathways Apoptosis Pathway Others Pathway 
Targets PROTAC Bcl2 

Structure

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