BCL2 Degrader C5 New
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CAS No. | 2378801-85-3 | Cat. No. | BCP36383 |
Name | BCL2 Degrader C5 | ||
Synonyms | PROTAC Bcl2 degrader-1; | ||
SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O | ||
Chemical Name | |||
Formula | C45H45BrN6O10S | M. Wt | 941.85 |
Purity | 98% | Storage | Store at 4-8°C |
Description | BCL2 Degrader C5 is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. |
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