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BCL2 Degrader C5 Chemical Structure

BCL2 Degrader C5

Data Sheet For research use only. Not for human use.
Cat. No. :BCP36383CAS No. :2378801-85-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2378801-85-3 Cat. No. BCP36383
Name BCL2 Degrader C5
Synonyms PROTAC Bcl2 degrader-1;
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O
Chemical Name
Formula C45H45BrN6O10S M. Wt 941.85
Purity 98% Storage Store at 4-8°C
Description BCL2 Degrader C5 is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
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