BB-Cl-Amidine hydrochloride
| CAS No. | BB-Cl-AmidineHCl | Cat. No. | BCP36632 |
| Name | BB-Cl-Amidine hydrochloride | ||
| Synonyms | BB-Cl-Amidine HCl; | ||
| Formula | C26H27Cl2N5O | M. Wt | 496.43 |
| Description | BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.BB-Cl-Amidine is a Novel Therapeutic for Canine and Feline Mammary Cancer via Activation of the Endoplasmic Reticulum Stress Pathway. BB-Cl-Amidine is a modified version of Cl-amidine that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-CLA reduced viability and tumorigenicity of canine and feline mammary cancer cell lines in vitro. BB-CLA activates the endoplasmic reticulum stress pathway in these cells by downregulating 78 kDa Glucose-regulated Protein (GRP78), a potential target in breast cancer for molecular therapy, and upregulating the downstream target gene DNA Damage Inducible Transcript 3 (DDIT3). |
Structure
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